微针和皮下针插入的新型立体声DIC特征
Megan McNamee1,2, Thomas Pritchard1, Jacob Mitchell3
1Biomedical Engineering Simulation and Testing Laboratory, Swansea University, Swansea, United Kingdom.
Frontiers in bioengineering and biotechnology
|July 15, 2025
概括
空洞的微针阵列对皮肤的压力比皮下针减少75%,为药物输送提供了更温和的替代方案,并可能改善患者的舒适度.
科学领域:
- 生物医学工程 生物医学工程
- 材料科学 材料科学 材料科学
- 皮肤病学 皮肤病学
背景情况:
- 微针是用于无痛药物输送的最小侵入性设备.
- 在微针插入和下皮针插入期间量化皮肤应变对于设备开发至关重要.
研究的目的:
- 用于量化通过空心微针和25度皮下针对皮肤模仿膜施加的最大正常应变.
- 为了在插入过程中比较微针阵列和传统针之间的应变水平.
主要方法:
- 利用了一种新的数字图像相关性设置来进行应变量化.
- 经过测试的空洞微针阵列和25尺不钢下皮针.
- 在接触,变形,破裂和插入阶段分析了应变.
主要成果:
- 与25度皮下针相比,空心微针阵列显著降低了最大正常应变.
- 通过微针装置观察到最大正常应变的平均75%降低.
- 应变量被量化每针,使得设计优化为未来的微针代.
结论:
- 空洞的微针装置为通过皮肤输送药物提供了更温和的替代方案.
- 这些发现表明,与皮下注射针相比,患者舒适度提高,组织创伤减少.
- 量化菌株数据支持对先进的微针技术进行明智的设计选择.
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