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Updated: Sep 15, 2025

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截断ASXL1突变驱动白血病对T细胞攻击的抵抗力.

Dustin McCurry, Zhongqi Ge, Jaehyun Lee

    bioRxiv : the preprint server for biology
    |July 15, 2025
    PubMed
    概括

    在ASXL1中发生的突变通过抑制白血病中的HLA-I表达来驱动对捐赠淋巴细胞输液 (DLI) 免疫疗法的耐药性. 抑制EZH2可以克服这种免疫逃避,恢复ASXL1-突变瘤中的T细胞杀死.

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