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Updated: Sep 15, 2025

Reconstitution of a Transmembrane Protein, the Voltage-gated Ion Channel, KvAP, into Giant Unilamellar Vesicles for Microscopy and Patch Clamp Studies
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Reconstitution of a Transmembrane Protein, the Voltage-gated Ion Channel, KvAP, into Giant Unilamellar Vesicles for Microscopy and Patch Clamp Studies

Published on: January 22, 2015

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截断的BK通道电压激活的原子模拟

Zhiguang Jia1, Jianhan Chen1

  • 1Department of Chemistry, University of Massachusetts, Amherst, MA 01003, USA.

bioRxiv : the preprint server for biology
|July 15, 2025
PubMed
概括

长时间模拟显示了大 (BK) 通道中电压传感器领域的明显移动. 温和的S4螺旋运动,加上电场梯度,通过非正规路径驱动BK通道门.

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Ion channels are specialized proteins on the plasma membrane that allow charged ions to pass down their electrochemical gradient. Their main function is to maintain the membrane potential which is critical for cell viability. These channels are either gated or non-gated and can transport more than a thousand ions within milliseconds for the cellular event to occur.
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