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Updated: Sep 15, 2025

Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death
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Published on: December 27, 2016

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酸化诱导的奇米拉重新连接致癌酶以触发亡

Manuel L Merz1, Veronika M Shoba1, Rajaiah Pergu1,2,3

  • 1Chemical Biology and Therapeutics Science Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.

bioRxiv : the preprint server for biology
|July 15, 2025
PubMed
概括

研究人员开发了一种新型的酸化诱导化学小分子 (PHICS),用于控制像BCR-ABL.L.这样的过度活跃酶. 这种事件驱动的方法提供了一种新的抗癌策略,克服了对传统药物的耐药性.

关键词:
在 BCR-ABLL 中.通过CRISPR抑制器扫描进行扫描.物理 物理 物理 物理事件驱动的药理学诱导的亲近性诱导的亲近性酸化的方法是:光化.耐药性的发展 耐药性的发展

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