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JIP4 缺乏导致由受损的囊流量引起的溶酶体储存疾病

Layla M Nassar1,2,3, Xiaojian Shi4,5,6, Agnes Roczniak-Ferguson1,2,3

  • 1Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut 06510, USA.

bioRxiv : the preprint server for biology
|July 15, 2025
PubMed
概括

JIP4蛋白通过调节囊素 (CTNS) 丰富度来控制 lysosomal 囊素水平. 失去JIP4会导致囊的积累,模仿 lysosomal储存疾病的囊病.

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