不规律的孕产妇护理诱导了早期生活逆境的小鼠模型中的回避者类依恋缺陷
Zoë A MacDowell Kaswan1, Christian Bowers1, Ivan Teplyakov1
1Department of Psychiatry, Yale University School of Medicine, 300 George Street, Suite 901, New Haven CT, 06511, USA.
bioRxiv : the preprint server for biology
|July 15, 2025
概括
在小鼠中,有限的床和巢 (LB) 扰乱了母亲的护理,导致后代的压力激素升高和回避性依恋行为,影响了他们的社交互动和焦虑水平.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 动物行为 动物行为
背景情况:
- 附件理论对于理解早期生活逆境的影响至关重要.
- 不安全的依恋方式与负面的健康结果有关.
- 人们对依恋的神经基础知之甚少,特别是在小鼠身上.
研究的目的:
- 研究有限的床和巢 (LB) 对小鼠的依恋行为的影响.
- 使用家庭监测来将异常的孕产妇护理与依恋缺陷联系起来.
- 探索受损孕产妇护理的神经和行为相关性.
主要方法:
- 在暴露于LB条件的小鼠中,对母婴护理的家庭监测.
- 测量幼的皮质水平和生长轨迹.
- 评估依恋类行为,包括发声,堤方法和各种产后天的焦虑类行为.
主要成果:
- 低腰表现出增加的母体碎片化和升高的幼皮质.
- 在分离过程中,LB幼表现出减少的发声,延迟的堤接近,以及增加的焦虑类行为.
- 某些行为,如母亲的缓冲和偏好,不受LB的影响.
结论:
- 在小鼠中,有限的床和巢 (LB) 诱导了避开类型的依恋缺陷.
- 由于LB导致的异常孕产妇护理会对后代的社会行为和应激反应产生负面影响.
- 这项研究为研究依恋障碍的神经生物学基础提供了一个模型.
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