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怀孕期间环境温度对新生儿出生体重的影响
Reshma Nargund1, Joddy Marchesoni2, Akshay Bareja3,4
1Nicholas School of the Environment, Duke University, Durham, NC, 27708, United States.
bioRxiv : the preprint server for biology
|July 15, 2025
概括
怀孕后期,特别是第三个三个月的高环境温度与新生儿出生体重增加有关. 这种效应在男性婴儿中显得更强烈,这表明温度定时对胎儿发育至关重要.
科学领域:
- 环境健康 环境健康
- 围产期流行病学 围产期流行病学
- 生殖健康 生殖健康
背景情况:
- 产前暴露于环境因素,如环境温度,可以影响胎儿的发育和出生结果.
- 了解怀孕期间温度影响的时间和程度对于公共卫生干预至关重要.
研究的目的:
- 评估怀孕期间环境温度暴露与新生儿出生体重之间的关联.
- 用先进的统计建模来识别温度暴露的敏感窗口.
主要方法:
- 使用了处罚的通用添加模型 (GAM) 框架与分布式滞后非线性模型 (DLNM).
- 分析了SHIP研究中的238名参与者的数据,并将Daymet数据的每周最高温度纳入其中.
- 调整为关键的母亲和婴儿共变量,包括母亲的年龄,BMI,妊娠年龄,种族,吸烟,糖尿病和婴儿的性别.
主要成果:
- 在妊娠第三季度,特别是最后几周,环境温度较高与出生体重增加有关.
- 分层分析表明,这种关联在男婴中更为明显.
- 该研究确定了对温度对出生体重的影响敏感的特定妊娠窗口.
结论:
- 产前暴露在高环境温度下,特别是在怀孕晚期,可能会对出生体重产生积极影响,性别差异显著.
- 妊娠期间暴露于温度的时间是确定其对新生儿出生体重的影响的一个重要因素.
- 研究结果强调需要考虑环境温度作为胎儿生长和新生儿健康的决定因素.
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