多变量静止状态功能连接特征与早期精神病症中跨诊断性精神病理相关
Haley R Wang1,2, Zhen-Qi Liu3, Jason S Nomi2
1Department of Psychology, University of California, Los Angeles, Los Angeles, CA, United States.
bioRxiv : the preprint server for biology
|July 15, 2025
概括
早期精神病 (EP) 涉及改变的大脑连接. 一项研究发现,EP的认知不灵活性和兴奋问题与大脑网络的特定静止状态功能连接 (RSFC) 模式有关.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 脑部成像 脑部成像
背景情况:
- 早期精神病 (EP) 呈现神经生物学变化,包括改变的静止状态功能连接 (RSFC).
- 现有研究表明,EP的诊断类别之间有症状和神经重叠.
- 在EP中,RSFC模式与跨诊断症状维度之间的准确联系需要进一步调查.
研究的目的:
- 研究整个大脑RSFC与早期精神病 (EP) 患者的临床症状之间的多变量关系.
- 确定与EP中的特定RSFC模式相关的跨诊断症状维度.
- 探索RSFC模式的潜力,以告知EP的有针对性的治疗方法.
主要方法:
- 在124名EP患者的休息状态功能连接 (RSFC) 数据上使用了部分最小方程相关性分析.
- 在216个皮层和皮下区域检查了RSFC.
- 评估了41个临床症状指标,包括正面,负面,一般精神病理和躁狂维度.
主要成果:
- 确定了与RSFC和症状相关的显著潜伏组件,解释了41.6%的共变量.
- 这一组件突出显示了感觉运动,默认模式和皮层下网络 (杏仁体,丘脑) 的连接性增加.
- 相关症状包括认知刚性和兴奋失调 (例如,刻板印象的思维,焦虑),而不是传统的积极/消极症状. 临床相关性通过与敌意,负面影响和感知压力的相关性得到证实.
结论:
- 发现了EP的跨诊断型表型,其特点是认知不灵活性和兴奋失调.
- 这种表型与感官,默认模式和皮层下大脑网络之间的整合发生变化有关.
- 研究结果表明,网络级的RSFC模式可能反映出超越诊断界限的症状维度,可能引导新的治疗策略.
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