体输出调节皮质回路的产后成熟
bioRxiv : the preprint server for biology
|July 15, 2025
概括
基底腺节的输出影响着发育中的大脑电路. 这项研究表明,小鼠早期的条纹活动塑造了背中前额叶皮层 (dmPFC) 的成熟.
科学领域:
- 神经科学是一个神经科学.
- 发育神经科学的发展神经科学.
- 系统神经科学 系统神经科学
背景情况:
- 背中前额叶皮层 (dmPFC) 和基底 (BG) 形成了对运动和认知功能至关重要的电路.
- 这些电路在出生后成熟,涉及神经活动变化和突触生长.
- 皮质活动在发展条状回路中的作用已知,但BG对皮质成熟的影响尚未被探索.
研究的目的:
- 调查早期产后发育期间的条状输出是否会影响上游dmPFC电路的活性和成熟.
- 为了了解基底质在皮质电路发展中的作用.
主要方法:
- 中等尺度的两光子显微镜.
- 全细胞电生理学全细胞电生理学
- 状脊柱投射神经元的有针对性的切除 (直接和间接的途径).
主要成果:
- 状神经元剥离诱导了dmPFC神经活动的双向变化,反映了成熟的电路模式.
- 操纵改变了dmPFC层2/3金字塔神经元中突触连接的成熟.
- 这些干预措施改变了皮质回路中的激发和抑制平衡.
结论:
- 在出生后早期的发育过程中,状输出在皮质电路活动中起着调节作用.
- 基底可能调节皮质电路的建立和成熟.
- 研究结果表明,基底和前额叶皮层之间存在互惠的发育关系.
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