控制肝细胞癌患者的营养状况评分的临床价值
Rongqiang Liu1, Lei Ji1, Chenxuan Zhang1
1Department of Hepatobiliary Surgery, Renmin Hospital of Wuhan University, Wuhan, China.
Frontiers in nutrition
|July 15, 2025
概括
控制营养状况 (CONUT) 评分是肝细胞癌 (HCC) 患者糟糕生存结果的重要预测指标. 这一元分析证实了CONUT得分.
科学领域:
- 在瘤学瘤学.
- 肝病学 肝病学是一种肝病学.
- 营养科学 营养科学
背景情况:
- 控制营养状况 (CONUT) 评分被认为对肝细胞癌 (HCC) 患者预后的重要性.
- 在HCC中CONUT得分的确切预后作用需要进一步澄清.
- 这项研究解决了更新元分析的需要,以准确定义HCC中CONUT得分的预后意义.
研究的目的:
- 调查诊断肝细胞癌 (HCC) 的患者控制营养状况 (CONUT) 评分的预后意义.
- 进行更新的元分析,巩固关于CONUT得分和HCC预后的现有证据.
- 评估CONUT得分和生存结果之间的关联,包括总生存率 (OS),无疾病生存率 (DFS),无复发生存率 (RFS) 和无进展生存率 (PFS).
主要方法:
- 在PubMed,Web of Science和Embase数据库中进行了系统的文献搜索,截至2024年10月23日.
- 提取了95%置信区间 (95%CI) 的危险比率 (HRs) 和几率比率 (ORs),并将它们汇总起来进行统计分析.
- 使用STATA软件 (12.0版本) 进行数据分析,以确定CONUT得分的预后值.
主要成果:
- 在分析中包括了19项包括7963名HCC患者的研究.
- 较高的CONUT得分与较差的生存结果显著相关:OS (HR: 1.58),DFS (HR: 2.06),RFS (HR: 1.48) 和PFS (HR: 1.93).
- 高的CONUT分数与瘤差异化 (OR: 1.32) 和多个瘤 (OR: 1.25) 相相关.
结论:
- 肝细胞癌 (HCC) 患者的CONUT分数升高显示出明显更差的生存预后.
- CONUT评分成为HCC患者的强大和有效的预后指标.
- 这些发现强调了CONUT评分在HCC风险分层和管理方面的临床实用性.
相关概念视频
Esophageal Varices-II: Clinical Features and Management
146
Esophageal varices often manifest as gastrointestinal bleeding episodes, presenting symptoms like hematemesis (vomiting of blood), hematochezia (passing fresh blood via the rectum), and melena (black, tarry stools). Other signs can include weight loss, anorexia, abdominal discomfort, jaundice, pruritus, altered mental status, and muscle cramps.
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...
146
Chronic Kidney Disease III: Interprofessional Care
81
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
81
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
426
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
426
Chronic Pancreatitis II: Collaborative Care
130
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
Assessment:
130
Chronic Kidney Disease IV: Nursing Management
59
Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of...
59
Nephrotic Syndrome II : Assessment and Medical Management
23
IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
23


