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使用一个三维打印的额外的雾化室,通过振动网状雾化器,用大量稀释剂进行素雾化:概念证明
Chao-Yu Chen1,2, Wei-Lun Liu3,4, Heng-Liang Lin5,6
1Department of Respiratory Therapy, Fu Jen Catholic University Hospital, Fu Jen Catholic University, New Taipei City, Taiwan.
European clinical respiratory journal
|July 15, 2025
概括
使用振动网状雾化器 (VMN) 进行合甲基 (CMS) 雾化时,较大的稀释剂容量可以减少残留晶体和粘度. 这表明,随着体积的增加,雾化效率有所提高.
科学领域:
- 呼吸系统药物 呼吸系统药物
- 制药技术 制药技术 制药技术
- 医疗器械工程 医疗器械工程
背景情况:
- 通过振动网状雾化器 (VMN) 给药的甲基 (CMS) 量受雾化室容量限制.
- 优化CMS输送对于有效的呼吸道治疗至关重要.
研究的目的:
- 为VMN设计和评估一种新的雾化室.
- 评估稀释剂体积对CMS雾化性能的影响.
主要方法:
- 一项实验室研究模拟了使用CMS与6毫升和12毫升稀释剂体积的7天临床场景.
- 在四个CMS稀释剂体积 (3,6,9,12毫升) 中分析了颗粒大小和粘度.
主要成果:
- 观察到残留胆固醇晶体,使用6毫升稀释剂的频率高于12毫升稀释剂.
- 在6毫升的体积下,VMN曾经出现过一次故障.
- 雾化胆固醇输出显示了与稀释剂粘度的逆相关性.
结论:
- 开发的雾化室使每次雾化过程中能够产生更大的CMS体积.
- 稀释剂量增加导致CMS残留晶体减少,粘度降低.
- 这表明,在较大的体积下,增强了雾化效率和设备可靠性.
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