在四个欧洲国家的可能耐火性慢性咳的患病率和负担
Javier Domínguez-Ortega1, J Christian Virchow2, Laurent Guilleminault3
1Department of Allergy, Hospital Universitario La Paz, Institute for Health Research (IDIPAZ), Madrid, Spain.
ERJ open research
|July 15, 2025
概括
患有慢性咳的成人中,多达27.9%的人可能患有耐火性慢性咳 (RCC). 这种情况与与不耐药慢性咳相比,更大的健康负担和医疗保健利用率增加有关.
科学领域:
- 肺部病理学 肺部病理学
- 流行病学 流行病学
- 医疗保健服务研究 医疗服务研究
背景情况:
- 慢性咳 (CC) 影响了相当一部分人口.
- 耐火性或无法解释的慢性咳 (RCC) 是一个具有挑战性的临床实体.
- 了解可能的RCC的患病率和负担对于患者护理至关重要.
研究的目的:
- 估计欧洲人口中可能存在的难治性或不明原因的慢性咳 (RCC) 的患病率.
- 评估与可能的RCC相关的健康相关负担.
- 确定区分可能的RCC与非RCC的特征.
主要方法:
- 来自法国,德国,意大利和西班牙的调查数据的二次分析.
- 纳入标准:当前慢性咳 (≥8周),不吸烟,没有肺癌史,间歇性肺病,或使用ACE抑制剂/口服类固醇.
- 根据咳严重程度评分 (≥4/10) 和≥1药物类别缺乏显著缓解来定义可能的RCC;基于≥2或3药物类别的子组.
主要成果:
- 在591名 (27.9%) 的CC受访者中,有165人符合可能的RCC标准.
- 可能的RCC组显示女性比例较高 (66.7%对57.3%),生活质量得分明显较低 (EuroQoL指数:0.72对0.80;莱斯特咳问卷:13.49对15.95).
- 可能的RCC组也有更多的医疗保健访问 (9.87对过去6个月的6.26).
结论:
- 大约有27.9%的慢性咳受研究的欧洲人口可能有耐火性慢性咳.
- 可能患有RCC的患者体验到与健康相关的负担大幅增加.
- 调查结果突出了对RCC更好的识别和管理策略的需要.
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