了解多发性硬化症自身血造干细胞移植中的微生物组
Jun Yin1, Nadeem O Kaakoush2, Jennifer Massey1,3,4
1UNSW School of Clinical Medicine, University of New South Wales, Sydney, NSW, Australia.
Frontiers in immunology
|July 15, 2025
概括
自主造血干细胞移植 (AHSCT) 改变了多发性硬化症 (MS) 患者的口腔微生物组,与纳塔利祖马布治疗相比,显示了物种丰富度的减少和细菌丰富度的改变. 这些变化可能表明MS的治疗状态或疾病活性.
科学领域:
- 微生物组研究的研究.
- 神经免疫学 神经免疫学
- 中枢神经系统疾病 中枢神经系统疾病
背景情况:
- 多发性硬化症 (MS) 是一种慢性中枢神经系统炎症性疾病,导致神经系统缺陷.
- 肠道微生物群影响中枢神经系统和免疫系统,并与MS有关.
- 自主造血干细胞移植 (AHSCT) 通过阻止炎症,有效治疗多发性硬化.
研究的目的:
- 研究AHSCT对MS患者口腔和肠道微生物群的影响.
- 将AHSCT治疗的多发性硬化患者的微生物组与纳塔利祖马布 (NTZ) 患者的微生物组进行比较.
主要方法:
- 16S rRNA基因扩增序列测序用于口腔和便微生物群分析.
- 在AHSCT和NTZ组之间比较微生物群多样性 (α和β) 和种群丰度.
- 在AHSCT队列中进行了纵向微生物组分析.
主要成果:
- 与NTZ组相比,AHSCT队列显示口腔物种丰富度显著降低 (p=0.026) 和口腔β多样性改变 (p=0.043).
- 在AHSCT组中,特定的口腔细菌Porphyromonas增加,而Veillonella减少.
- 试点研究确定了与多发性硬化症治疗或疾病活动潜在相关的显著微生物群变化.
结论:
- 在MS患者中,AHSCT显著影响口腔微生物组.
- 观察到的微生物组变化可以作为MS中治疗反应或疾病状况的生物标志物.
- 需要进一步的研究来阐明微生物组变化的作用在MS的AHSCT疗效.
相关概念视频
01:22Bone Marrow Sampling and Transplants
502
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
502
01:19Multipotency of Hematopoietic Stem Cells
3.3K
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
3.3K
01:24Tissue Transplantation
524
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
524
01:19Mesenchymal Stem Cells
5.0K
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
5.0K
01:01Regulation of Hematopoietic Stem Cells
3.3K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.3K