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除了校对之外:POLD1突变作为基因组不稳定性和癌症免疫逃避的动态编排者

Huiqing Chen1, Jiayu Wei1, Qi Tang1

  • 1School of Life Sciences, Jiangsu University, Zhenjiang, China.

Frontiers in immunology
|July 15, 2025
PubMed
概括

在DNA聚合酶三角子单元POLD1中的突变破坏了DNA修复,导致癌症. 意想不到的是,这些POLD1突变在微卫星稳定的瘤中增强了抗癌免疫力,改善了对免疫治疗的反应.

关键词:
DNA聚合酶三角酶是什么这种突变是POLD1突变.癌症 癌症 癌症 癌症 癌症基因组的不稳定性免疫疗法 免疫疗法

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