在炎症性肠病中,PD-L1 缺乏会通过重塑肠道微生物群来加剧结肠炎的严重程度
Yixian Ma1,2,3, Jinshan Suo4, Siqi Sheng1,2,3
1Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, China.
Frontiers in immunology
|July 15, 2025
概括
编程死亡配体1 (PD-L1) 缺乏会通过改变肠道细菌和损害微生物代谢,使炎症性肠病 (IBD) 恶化. 这突显了PD-L1在维持免疫和微生物组平衡方面的关键作用.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
- 胃肠病学 胃肠病学
背景情况:
- 炎症性肠病 (IBD) 是一种与肠道微生物群失调相关的慢性自身免疫性疾病.
- 编程死亡配体1 (PD-L1),一个免疫检查点,影响肠道微生物群的组成.
- 在IBD相关的大肠炎期间,PD-L1在塑造元基因组资料中的特定作用尚不清楚.
研究的目的:
- 在大肠炎小鼠模型中研究PD-L1在调节肠道微生物群和元基因组特征中的作用.
- 为了确定PD-L1缺乏如何影响硫酸 (DSS) 诱导的大肠炎的严重程度.
主要方法:
- 在野生类型 (wt) 和PD-L1淘汰赛 (Pdcd1lg1-/-) 小鼠中确立了德克斯硫酸 (DSS) 诱导的大肠炎.
- 评估了大肠炎严重程度的临床和组织病理学参数.
- 分析了元基因组概况和差异表达基因 (DEGs).
主要成果:
- PD-L1淘汰赛小鼠表现出明显恶化的结肠炎,包括更大的体重减轻,结肠缩短和疾病活动指数 (DAI) 成绩.
- PD-L1 缺乏导致明显的肠道失调,致使诸如大肠杆菌 (Escherichia coli) 之类的病原生物丰富,并使诸如Tritrichomonas foetus*之类的共生生物枯竭.
- 阿尔法多样性发生了显著的变化,KEGG途径分析显示了PD-L1淘汰赛小鼠与免疫和炎症途径的关联.
结论:
- 由于PD-L1缺乏,导致致病性微生物群的改变,并损害微生物代谢平衡,从而加剧结肠炎.
- 这项研究强调了PD-L1在维持免疫平衡和微生物组动态方面的双重调节作用.
相关概念视频
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
332
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
332
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
426
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
426
01:17Chronic Bowel Disorders: Introduction
541
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
541
01:30Inflammatory Bowel Disease II: Crohn's Disease
392
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
392
01:21Inflammatory Bowel Disease V: Surgical Management
221
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
Here are some common surgical interventions for IBD:
221
01:29Inflammatory Bowel Disease IV: Pharmacological Management
198
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
198