内分泌干扰化学物质与女性不孕症之间的关联:基于NHANES数据库的研究
Luo Bingru1, Chen Ting2, Zhang Zhe1
1Reproductive Medicine Center, The First-affiliated Hospital of Hunan Normal University (Hunan Provincial People's Hospital), Changsha, Hunan, China.
Frontiers in public health
|July 15, 2025
概括
暴露于内分泌干扰化学物质 (EDC),如酸盐和PFAS,与女性不孕症有关. 增加的年龄和BMI可能会加剧这些风险,强调需要EDC暴露预防策略.
科学领域:
- 环境健康 环境健康
- 生殖毒理学 生殖毒理学
- 内分泌学 在内分泌学.
背景情况:
- 内分泌干扰化学物质 (EDCs) 涉及女性不孕症,但具体的病因尚不清楚.
- 本研究使用NHANES数据调查了各种EDC代谢物与女性不孕症之间的关联.
研究的目的:
- 研究EDC代谢物暴露与女性不孕症之间的关系.
- 确定有助于女性不孕症的特定EDC.
主要方法:
- 来自NHANES (2001-2006) 的3,982名生育年龄女性 (18-45岁) 的横截面研究.
- 多变量逻辑回归分析,以评估EDC代谢物与不孕症的相关性.
- 根据年龄和BMI分析子组,结果以几率比率 (OR) 和95%置信区间 (CI) 报告.
主要成果:
- 在增加暴露于EDC代谢物 (DnBP,DEHP,DiNP,DEHTP,PAE,Equol,PFOA,PFUA) 和女性不孕症之间发现了显著的关联.
- 具体的ORs在1.34到2.10之间,表明风险增加.
- 亚组分析表明,年龄和BMI可能会加剧暴露于EDC的女性的不孕症风险.
结论:
- 暴露于特定的EDC代谢物,包括酸盐 (PAE) 和per-和多基物质 (PFAS),与女性不孕症有关.
- 这些发现支持针对EDC暴露的预防措施,以减少女性不孕症的发生率.
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