构建和验证心力衰竭患者认知障碍的诺莫格拉姆模型
Ni Chen1, Jie Liu2, Wenjia Liu1
1Office of Academic Research, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Frontiers in cardiovascular medicine
|July 15, 2025
概括
心力衰竭患者患有认知障碍的风险很高,往往诊断不足. 一个使用年龄,教育,心脏病,透缩功能和脆弱性的新模型有助于早期检测.
科学领域:
- 心脏病学 心脏病学
- 神经学 神经学
- 老年病的医生 老年病的医生
背景情况:
- 心力衰竭 (HF) 患者表现出明显增加的认知障碍风险.
- 在HF中认知障碍的低诊断很普遍,特别是在年轻的患者或有轻度症状的患者中.
- 早期识别至关重要,因为高频率的认知衰退会对预后产生负面影响.
研究的目的:
- 开发和验证用于早期识别心力衰竭患者认知障碍的预测工具.
- 支持临床决策,以便及时进行干预和管理.
主要方法:
- 使用逻辑回归和LASSO回归在320名HF患者的数据上构建了一个名图模型.
- 用蒙特利尔认知评估 (MoCA) 评估认知功能.
- 进行了内部和时间验证,对另外80名HF患者进行了验证.
主要成果:
- 认知障碍的发生率在模型组为68.75%,在验证组为56.25%.
- 确定的主要预测因素是年龄,教育水平,冠心病,心脏扩张功能和身体虚弱.
- 该模型表现出良好的预测性能,AUC为80.2% (内部) 和72.44% (时间验证).
结论:
- 开发的诺莫格拉姆模型表现出强大的临床可行性和高度的适合性.
- 该工具提供了一种可靠的方法,用于早期检测心力衰竭患者的认知障碍.
- 改善早期诊断可以带来更好的管理策略和更好的患者结果.
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