阐明生活方式干预措施减轻放射治疗不良影响的机制:范围审查
Oliver Chalmers1, Alex Waddell2,3, Ananya Choudhury4,5
1Department of Sport and Exercise Sciences, Institute of Sport, Manchester Metropolitan University, Manchester, UK.
BMJ oncology
|July 15, 2025
概括
包括饮食和运动在内的生活方式干预措施显示出减少放射治疗副作用的潜力. 需要进一步的研究来确认这些非药理选择的机制和疗效.
科学领域:
- 在瘤学瘤学.
- 辐射疗法 辐射疗法
- 生活方式 医学 医疗
背景情况:
- 放射治疗是癌症治疗的基石.
- 放射治疗通常会导致严重的副作用,影响患者的生活质量.
- 积极寻求用于减轻这些副作用的非药理学策略.
研究的目的:
- 审查关于生活方式干预机制的现有文献,以减轻放射治疗诱导的副作用.
- 确定潜在的非药物治疗选择,以管理放射治疗并发症.
主要方法:
- 使用乔安娜·布里格斯研究所的方法进行了范围审查.
- 在MEDLINE,CINAHL和CENTRAL数据库中进行了搜索,截至2024年3月13日.
- 包括专注于接受放射治疗的成人癌症患者的研究,检查生活方式干预措施及其对结果的影响.
主要成果:
- 包括9项研究,涵盖了各种癌症类型和干预时间.
- 生活方式干预包括营养补充剂,饮食,传统中医和炼 (抵抗和有氧运动).
- 观察到的好处包括改善特定部位的毒性,炎症标志物,以及潜在的预防体重减轻和虚弱.
结论:
- 生活方式干预在减轻放射治疗副作用方面表现有前途.
- 机制包括调节炎症反应,并可能准骨肌肉代谢.
- 需要进一步的研究来确定一致的疗效,并充分阐明潜在的机制.
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