长期认知障碍中的神经炎症在动脉瘤下arachnoid 出血后
Reinier Wp Tack1, Nelleke Tolboom2, Bas Meyer Viol3
1Department of Neurology and Neurosurgery, UMC Utrecht Brain Center, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands.
概括
动脉瘤下arachnoid出血 (aSAH) 后的长期认知障碍与神经炎症无关. 微观结构性脑损伤,而不是炎症,似乎与aSAH幸存者的认知缺陷有关.
科学领域:
- 神经科学是一个神经科学.
- 放射学 放射学是一门学科.
- 神经学 神经学
背景情况:
- 肺动脉瘤下关节出血 (aSAH) 的幸存者经常经历认知障碍.
- 长期的神经炎症是这种认知衰退的潜在原因,但尚未得到证实.
研究的目的:
- 研究长期神经炎症和微观结构性脑损伤与aSAH幸存者的认知障碍之间的关联.
- 确定神经炎症或微观结构变化是否是aSAH后认知缺陷的主要驱动因素.
主要方法:
- 对患者的前性队列研究>3年后aSAH (2020-2022).
- 神经心理评估,[18F]DPA-714 TSPO PET成像用于神经炎症,以及微观结构损伤的扩散曲解成像 (DKI).
- 在认知受损和未受损组之间,TSPO PET结合潜力和DKI指标 (MK,KA,AK,RA) 的比较.
主要成果:
- 两组之间全脑TSPO结合潜力 (神经炎症) 没有显著差异.
- 患有认知障碍的患者表现出较低的全脑平均缩症 (MK) 和轴性缩症 (AK).
- 左丘脑MK和AK与口头记忆性能相关,这表明微观结构损伤的作用.
结论:
- 长期的神经炎症似乎不会导致aSAH后的认知障碍.
- 微观结构性脑损伤,特别是在丘脑,与aSAH幸存者的认知缺陷有关.
- 研究结果表明,在aSAH后的长期认知结果中,微观结构变化比神经炎症更为关键.
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