在患有乳病的患者中,自身免疫性胃炎的患病率和预测因素
Ramazan Erdem Er1, Volkan Yilmaz1, Yigit Baykara2
1Gastroenterology, İbn-I Sina Hospital, Ankara University Medical School, Ankara, Turkey.
概括
结核病 (CD) 和自身免疫性胃炎 (AIG) 经常同时存在. 马什2型CD和负抗内分泌体IgA是查患有乳病患者自身免疫性胃炎的关键预测因子.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 内部医学 内部医学
背景情况:
- 乳病 (CD) 是一种免疫媒介的谷蛋白不耐受.
- 自身免疫性胃炎 (AIG) 涉及对胃H+/K+-ATPase和内在因子的自身抗体.
- 这两种情况都会导致营养吸收不良和贫血.
研究的目的:
- 为了确定CD患者中AIG的患病率.
- 在患有CD的个体中识别AIG的预测因子.
主要方法:
- 分析了183名CD患者.
- 数据包括人口统计,自身免疫性并发症,血清学和营养水平.
- 通过马什分类诊断的CD;通过组织病理学的AIG.
主要成果:
- 10.4%的CD患者 (19/183) 同时患有AIG.
- 沼泽类型2 CD (OR 15.8) 和缺乏抗内分泌体IgA (OR 0.26) 预测了AIG.
- 多变量分析证实了这些预测因素.
结论:
- AIG影响超过10%的乳病患者.
- 马什2型CD和负抗内分泌体IgA是显著的预测因素.
- 在具有这些特征的CD患者中建议对AIG进行查.
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