与胃食道逆流性疾病相关的Helicobacter pylori感染和消灭
Hejie Wang1, Yaxin Qu1, Yuan Lin1
1School of Public Health, Fujian Medical University, Fuzhou, China.
Journal of gastroenterology and hepatology
|July 15, 2025
概括
杆菌感染似乎降低了胃食道逆流性疾病 (GERD) 的风险. 然而,根除H. pylori可能会增加患有GERD的可能性,特别是反流性食道炎.
科学领域:
- 胃肠病学 胃肠病学
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 杆菌 (H. pylori) 感染和胃食道逆流症 (GERD) 之间的关系仍然不完全理解.
- 现有研究提出了关于H. pylori对GERD发展和进展的影响的相互矛盾的发现.
研究的目的:
- 系统地评估H. pylori感染和根除与随后的GERD风险之间的关联.
- 澄清H. pylori在GERD病变发生过程中的病因作用.
主要方法:
- 进行了前性研究 (队列,嵌套病例控制,RCT) 的系统审查和元分析.
- 在Embase,Medline和Cochrane图书馆进行文献搜索,截至2024年5月.
- 使用FinnGen数据的门德尔随机分析评估了H. pylori抗体和GERD风险.
主要成果:
- 对4项研究的元分析表明,H. pylori感染和GERD之间的反向关联 (OR=0.58).
- 对20项研究的分析显示,H. pylori根除后,GERD的风险增加 (OR=2.01),与逆流食道炎 (OR=2.27) 有较强的关联.
- 门德尔的随机化分析发现,H. pylori抗体与GERD风险之间没有显著的关联.
结论:
- 杆菌感染与患有GERD的风险降低有关.
- 根除H. pylori似乎会增加发生GERD的风险,包括逆流性食道炎.
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