卡瓦克罗尔的同时使用改善了老鼠的兰巴达-赛哈洛特林诱导的外周神经病变:行为和分子证据
Özge Kandemir1, Mustafa İleritürk2, Cihan Gür3
1Department of Food Processing, Aksaray Technical Sciences Vocational School, Aksaray University, Aksaray, Turkey.
Journal of biochemical and molecular toxicology
|July 15, 2025
概括
卡瓦克罗尔 (CRV) 显示出对Lambda-cyhalothrin (CYH) 诱导的外周神经病变的神经保护作用. 在老鼠中,CRV治疗改善了神经功能,减少了氧化应激,并抑制了炎症和亡.
科学领域:
- 神经科学是一个神经科学.
- 毒理学 毒理学 毒理学
- 药理学 药理学是指药理学的学科.
背景情况:
- 周围神经病变是一种严重的健康问题.
- 兰巴达-甲 (CYH) 是一种广泛使用的杀虫剂,可以诱导神经毒性.
- 卡瓦克罗 (Carvacrol,简称CRV) 是一种具有潜在治疗功能的天然化合物.
研究的目的:
- 为了研究Carvacrol (CRV) 对鼠模型中Lambda-cyhalothrin (CYH) 诱导的外周神经病变的神经保护潜力.
- 评估CRV对感觉和运动功能的影响,氧化应激,炎症,细胞亡和内分泌网膜应激在CYH治疗的老鼠中.
主要方法:
- 35只老鼠被分配到五个组:对照组,CRV,CYH,CYH+CRV25和CYH+CRV50.
- 动物在21天内口服CRV (25或50毫克/公斤) 和CYH (6.23毫克/公斤).
- 评估包括行为测试 (热板,旋转杆),分子,生物化学,遗传学和免疫组织化学分析的坐骨神经组织.
主要成果:
- 服用CYH显著损害了感觉和运动功能,增加了氧化应激标志物 (MDA) 和降低了抗氧化剂水平.
- 治疗CRV (25和50毫克/公斤) 显著改善了神经功能,并逆转了氧化应激.
- 通过使用CRV抑制了炎症,亡和内质网膜应激,50mg/kg的剂量显示出更大的疗效. 此外,CRV还降低了8-OHdG和贝克林-1免疫反应,表明神经损伤的部分修复.
结论:
- CYH通过炎症,氧化应激,ER应激和 sciatic组织的亡诱导了外围神经病变.
- 卡瓦克罗尔具有显著的抗氧化,抗炎和抗质性质.
- CRV显示出作为减轻CYH诱导的坐骨神经损伤的支持性治疗剂的潜力.
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