S100A8/S100A9 影响能量消耗和全身新陈代谢
Anat Neumann1,2, Irina Efimova1,2, Inbar Shteinberg1,2
1The Research Center for Digestive Tract and Liver Diseases, Tel Aviv Sourasky Medical Center and Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel.
概括
炎症警报剂S100A8/S100A9对热生成和能量消耗产生负面影响. 它的缺失改善了新陈代谢健康,减少了肥胖,突出了它在能量恒温中的作用.
科学领域:
- 代谢性疾病研究研究.
- 脂肪组织生物学 脂肪组织生物学
- 肥胖和糖尿病的研究研究.
背景情况:
- 热生脂肪组织是肥胖和2型糖尿病的治疗点.
- S100A8/S100A9是一种与肥胖和其他疾病相关的炎症警报剂.
研究的目的:
- 研究S100A8/S100A9在发热和全身能量恒温中的作用.
- 为了确定S100A8/S100A9是否影响饮食引起的肥胖和代谢功能障碍.
主要方法:
- 在高脂肪饮食中比较野生型和S100A8/S100A9缺乏的小鼠.
- 通过暴露于寒冷和β-上腺素刺激来评估发热反应.
- 在体外研究中,使用S100A9.9刺激的色脂肪细胞.
主要成果:
- 在饮食诱导的肥胖中,S100A8/S100A9缺乏会减少体重增加,改善胰岛素敏感性和减弱肝肥.
- 缺少S100A8 / S100A9增加了氧气消耗,热量产生和 inguinal 白脂肪组织.
- 外源性S100A8/S100A9抑制了 inguinal 白脂肪组织中的热原性基因表达.
结论:
- S100A8/S100A9 作为 inguinal 白脂肪组织的负调节剂和能量消耗.
- S100A8/S100A9有助于降低代谢平衡,并加剧饮食引起的肥胖.
- 针对S100A8/S100A9可能为肥胖和相关代谢障碍提供治疗策略.
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