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Updated: Sep 15, 2025

Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production
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干扰素刺激的cirHOMER1减弱了抗病毒天生的免疫力

Ao Zhang1, Ranran Yao1, Shijin Geng1

  • 1Department of Immunology, School of Basic Medical Sciences, NHC Key Laboratory of Medical Immunology, Medicine Innovation Center for Fundamental Research on Major Immunology-related Diseases, Peking University, Beijing, China.

mBio
|July 15, 2025
PubMed
概括

循环RNA circHOMER1通过抑制I型干扰素信号传递和促进病毒复制来抑制抗病毒免疫力. 这种新发现的干扰素刺激的circRNA在维持免疫平衡中起着至关重要的作用,可能是病毒感染的治疗点.

关键词:
在RIG-I中,RIG-I是指RIG-I.ceRNARNA是什么意思在CircHOMER1中,这是先天免疫力.在 miR-145-3p 中使用.

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