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Updated: Sep 15, 2025

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
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使用DegradeMaster精确的PROTAC目标降解预测

Jie Liu1, Michael J Roy1, Luke Isbel1,2

  • 1South Australian Immunogenomics Cancer Institute (SAiGENCI), The University of Adelaide, Adelaide, South Australia 5005, Australia.

Bioinformatics (Oxford, England)
|July 15, 2025
PubMed
概括

新的人工智能工具DegradeMaster通过使用3D分子结构和未标记的数据,准确地预测蛋白质溶解向嵌合体 (PROTAC) 降解能力. 这促进了向蛋白质降解,并加速了药物发现.

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