有证据表明,在患有新兴情绪障碍的年轻人中,昼夜节律的内部错位
Joanne S Carpenter1, Jacob J Crouse1, Mirim Shin1
1Youth Mental Health and Technology Team, Brain and Mind Centre, The University of Sydney, Sydney, NSW, Australia.
Journal of biological rhythms
|July 15, 2025
概括
循环节律障碍,包括内体时钟标志物如黑激素和体温的错位,在情绪障碍的年轻人中很常见. 这种错位与抑郁症状严重程度的增加有关.
科学领域:
- 时间生物学 时间生物学
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
背景情况:
- 循环节功能障碍与情绪障碍有关,但研究往往侧重于单个标志物.
- 现有研究表明,在严重抑郁症中,内部相位标志物 (例如,暗光黑激素发作[DLMO],皮质醇峰值) 的 misalignment.
- 更大的错位可能与更严重的抑郁症状相关.
研究的目的:
- 研究年轻人出现情绪障碍的多个昼夜阶段标志物.
- 为了确定这个人群是否存在内部昼夜失调.
- 评估昼夜失调程度与情绪症状严重程度之间的相关性.
主要方法:
- 对69名患有新兴情绪障碍的青少年和19名健康对照者的横截面研究.
- 使用动图,在实验室测量DLMO,唾液皮质醇峰值 (CORT) 和核心体温极点 (TEMP).
- 通过使用汉密尔顿抑郁评分表来评估抑郁症状.
主要成果:
- 与其他标志物相比,较早的核心体温最低点 (TEMP) 与较高的抑郁症状有关.
- 23%的新兴情绪障碍的年轻人表现出至少两个昼夜标志物之间的异常相角.
- 内部错位子组平均显示较晚的DLMO,具有各种各样的个体异常.
结论:
- 在患有精神疾病的年轻人中观察到昼夜调整的各种障碍.
- 核心体温和黑激素节律的相对时间可能是与抑郁症状有关的关键指标.
- 需要进行纵向研究,以探索纠正昼夜失调是否有助于治疗青少年情绪障碍.
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