孕期暴露于颗粒物和孕前风险:来自元分析和孟德尔随机化研究的证据
Ruilin Ma1, Yanan Li1, Jianjian Cui1
1Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Journal of clinical hypertension (Greenwich, Conn.)
|July 15, 2025
概括
怀孕期间暴露于颗粒物 (PM) 可能与产前 (PE) 风险有关,特别是在第二个三个月. 然而,遗传分析没有证实因果关系,这表明在解释观察结果时要谨慎.
科学领域:
- 环境健康 环境健康
- 生殖流行病学 生殖流行病学
- 毒理学 毒理学 毒理学
背景情况:
- 孕前 (PE) 是一种严重的妊娠并发症,其特征是高血压.
- 环境因素,包括对颗粒物 (PM) 的暴露,正在被调查为可能导致PE发展的潜在因素.
- 微细颗粒,如PM2.5和PM10,由于它们能够深入呼吸系统而引起特别关注.
研究的目的:
- 调查暴露于颗粒物 (PM) 和产前 (PE) 风险之间的关联.
- 用孟德尔随机化 (MR) 分析评估潜在的因果关系.
- 探索从观察性研究中发现的异质性.
主要方法:
- 进行了对26项研究的元分析,包括超过200万例怀孕.
- 门德尔随机化 (MR) 分析利用了来自欧洲全基因组关联研究的遗传数据.
- 进行了子组和元回归分析,以评估异质性的来源.
主要成果:
- 分析显示了PM暴露和PE风险之间的温和关联,特别是第二个三个月的PM2.5 (OR=1.03) 和PM10暴露 (OR=1.06).
- 观察到显著的异质性,主要归因于区域差异 (欧洲与亚洲).
- 对MR的分析没有支持PM暴露和PE风险之间的因果关系.
结论:
- 观察性研究表明,怀孕中期的PM暴露与增加PE风险之间存在关联.
- 在MR分析中缺乏因果关系凸显了观察数据中的潜在混,暴露错误分类和异质性.
- 在PM暴露和PE之间观察到的关联应谨慎解释.
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