双相酸骨替代材料的新骨形成:随机对照试验 (RCT) 的系统审查和网络元分析
Chutikarn Somngam1, Sutiwat Samartkit1, Sukrit Kanchanasurakit2,3,4,5
1Center of Excellence for Dental Implantology, Faculty of Dentistry, Chiang Mai University, Chiang Mai, 50200, Thailand.
International journal of implant dentistry
|July 15, 2025
概括
双相酸盐 (BCP) 在牙科植入物中显示出良好的骨形成,表现优于异端移植. 虽然自体移植和异体移植是优越的,但BCP是一种有效的骨替代材料.
科学领域:
- 生物材料科学 生物材料科学
- 再生医学是一种再生医学.
- 口腔和牙面部外科手术
背景情况:
- 骨替代材料 (BSM) 对于牙科植入物治疗至关重要,特别是在鼻增大方面.
- 双相酸盐 (BCP) 是一种常用的BSM,但其相对于其他材料的有效性需要进行系统的评估.
- 了解不同BSM的相对新骨形成能力对于优化治疗结果至关重要.
研究的目的:
- 系统地比较双相酸盐 (BCP) 与其他骨替代材料 (BSM) 在牙科植入物治疗中新骨形成的有效性.
- 进行网络元分析 (NMA) 以根据其基因组形计新骨形成来对BSM进行排名.
- 为了评估BCP在侧侧鼻膜增大手术中的性能.
主要方法:
- 在MEDLINE,Cochrane,Scopus和Embase进行了系统的文献搜索,直到2024年11月,遵守PRISMA-NMA指南.
- 包括随机对照试验 (RCT),将BCP与其他BSM (自体移植,异体移植,β-三酸,异体移植) 对新骨形成进行比较.
- 质量评估使用了Cochrane偏差风险2 (RoB2.0) 工具,随机效应模型和SUCRA评分用于治疗排名.
主要成果:
- 分析了11项涉及283名患者和362名鼻增大手术的研究.
- 与BCP相比,自体移植显示出明显更多的新骨形成 (12.33%). 此外,所有移植也显示了更多的骨形成 (5.14%).
- 与BCP相比,外来移植的骨质形成较少 (4.14%) 和残留移植物质最多 (6.21%) .
结论:
- 双相酸盐 (BCP) 是一种有效的骨替代材料,显示出足够的新骨形成,性能优于异种移植.
- 虽然自体移植和异体移植提供了卓越的骨再生,但BCP在牙科植入学中为骨增强提供了可行的替代方案.
- 这些发现支持在自体移植或异体移植可能不可行或不最佳的情况下使用BCP.
更多相关视频
08:41Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials
Published on: August 13, 2019
8.4K
09:35Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
Published on: September 11, 2015
9.8K
相关概念视频
Bone Remodeling
38.5K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
38.5K
The Bone Matrix
4.5K
Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in...
4.5K
Bone Formation by Intramembranous Ossification
7.6K
Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into ...
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into ...
7.6K
Fractures: Bone Repair
3.7K
Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...
3.7K
Osteoclasts in Bone Remodeling
3.2K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
3.2K
