副益生菌减轻炎症和焦虑类行为在一个脂聚糖诱导的小鼠模型
Monique Michels1,2, Gabriel Fernandes Alves Jesus2, Emily Córneo1
1Laboratory of Experimental Pathophysiology, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, Brazil.
Current microbiology
|July 15, 2025
概括
包括B. lactis,S. thermophilus和L. casei在内的偏微生物改善了急性炎症小鼠的焦虑和肠道健康. 这些补充剂降低了炎症标志物,并保护了肠道完整性免受脂多糖 (LPS) 的侵害.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 神经科学是一个神经科学.
背景情况:
- 急性炎症可能导致显著的生理障碍,包括焦虑类行为和肠道健康受损.
- 脂多糖 (LPS) 是一种强大的内毒素,用于诱导急性炎症并研究其影响.
- 目前正在研究其潜在的健康益处,即被禁用的微生物细胞.
研究的目的:
- 在LPS诱导的急性炎症小鼠模型中,评估五种类型类生物对焦虑性行为,肠道健康和炎症/氧化应激标志物的影响.
- 为了识别特定的偏益生物菌株,对炎症和相关行为产生有益影响.
- 评估对肠道完整性和屏障功能的保护作用.
主要方法:
- 雄性Balb/C小鼠在15天内补充了副益生菌或盐水.
- 使用脂聚糖 (LPS) 诱导了急性炎症.
- 评估了类似焦虑的行为,血清细胞因子水平 (IL-1β,IL-6,IL-10),髓氧化酶活性,酸盐/酸盐水平,脂质过氧化和肠道组织学.
主要成果:
- 偏微生物B. lactis,S. thermophilus和L. casei在LPS后改善了类似焦虑的行为.
- 所有补充的偏益生物降低了血清IL-1β和血液,肠道和大脑中的髓氧化酶活性.
- L. casei 特别减少了 IL-6; 副益生菌预防了 LPS 引起的肠损伤,并保持了肠道完整性.
结论:
- 辅助生物补充剂,特别是B. lactis,S. thermophilus和L. casei,在急性炎症中有效地减轻类似焦虑的行为.
- 偏益生菌显示出显著的抗炎和抗氧化特性,减少关键的炎症标志物和保护肠道屏障功能.
- 这些发现突出了对抗生素在治疗炎症相关疾病及其相关的行为和生理后果方面的治疗潜力.
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