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PepMapViz:用于类映射,可视化和比较探索的多功能工具包

Zhenru Zhou¹, Qui T Phung¹, Corey E Bakalarski^1,2

¹Department of Proteomic and Genomic Technologies, Genentech, Inc., South San Francisco, CA 94080, United States.

Bioinformatics (Oxford, England)

|July 15, 2025

概括

PepMapViz是一个新的R包,用于可视化质谱测量中的片映射数据. 它有助于理解蛋白质域,修改,并预测抗体疗法的免疫性.

科学领域:

蛋白质组学和生物信息学
免疫学和药物开发

背景情况:

质谱学对于识别和分析蛋白质修饰至关重要.
在不同的分析工具和实验条件中可视化数据具有挑战性.

研究的目的:

介绍PepMapViz,这是一个用于片映射和可视化的多功能R包.
为了方便从各种质谱仪器中导入和分析类数据.
通过可视化增强对基于抗体的疗法的免疫性预测.

主要方法:

PepMapViz从多个质谱分析工具中导入类数据.
该包将基映射到父蛋白序列,突出显示域和修改.
支持跨实验条件的比较可视化.

主要成果:

PepMapViz可以在抗体区域中可视化MHC呈现的类群.
它有助于在类水平上可视化跨软件质谱结果.
该包可视化域名细节和翻译后修改覆盖范围.

结论:

PepMapViz提供灵活的酸映射和可视化功能.
它支持复杂的蛋白质组学数据的分析,并有助于药物开发.
该R包是免费可用的,用于使用和进一步开发.

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