在检测辐射诱导肺损伤 (RILI) 的非侵入性成像技术的进展
Austen Nissen1,2, Said H Audi2,3,4, Anne V Clough2,3,5
1Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI, USA.
International journal of radiation biology
|July 15, 2025
概括
非侵入性成像技术可以早期检测辐射诱导的肺损伤 (RILI). 这些方法提供了关于RILI机制的见解,如炎症和纤维化,指导癌症治疗和辐射暴露反应.
科学领域:
- 辐射生物学 辐射生物学
- 医疗成像医学成像
背景情况:
- 辐射诱导的肺损伤 (RILI) 是癌症患者和辐射事故受害者的关键毒性.
- 早期发现RILI对于指导辐射治疗 (RT) 计划和暴露个体的治疗决策至关重要.
研究的目的:
- 审查用于检测辐射诱导肺损伤 (RILI) 的非侵入性成像技术的进展.
- 突出成像生物标志物的潜力,以了解RILI进展.
主要方法:
- 对RILI目前的非侵入性成像方式的审查.
- 包括计算机断层扫描 (CT),磁共振 (MR),高极化MR,核医学 (PET,SPECT) 和近红外 (NIR) 光学成像.
主要成果:
- 各种成像技术显示出早期RILI识别的前景.
- 这些模式可以非侵入性地检测关键的RILI机制.
结论:
- 非侵入性成像提供了RILI的早期检测.
- 成像可以提供RILI的机械洞察力,包括炎症,血管损伤,细胞死亡,氧化应激和纤维化.
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