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Updated: Sep 15, 2025

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在瘤中剖析无细胞DNA碎片变异,使用细胞系衍生异种移植小鼠

Ruiqing Fu1, He Amy Su2, Yi Zhao3

  • 1Singlera Genomics (Shanghai) Ltd., Shanghai, China.

PloS one
|July 15, 2025
PubMed
概括

无细胞DNA (cfDNA) 碎片化模式揭示了癌症的洞察力. 短cfDNA片段在瘤中被丰富,具有明显的模式,区分细胞系和解剖部位.

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Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
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