相关实验视频

Updated: Sep 15, 2025

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
05:10

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Published on: December 11, 2016

9.7K

一种基于等级的注意力负采样方法用于药物重新定位,使用邻近互动融合

Chenglong Mi, Lingyun Dai, Junliang Shang

    IEEE journal of biomedical and health informatics
    |July 15, 2025
    PubMed
    概括

    这项研究引入了HA-NegS,这是一种通过改进负采样来预测药物疾病关联的新型模型. HA-NegS增强了药物重新定位和治疗策略的开发.

    更多相关视频

    Diagonal Method to Measure Synergy Among Any Number of Drugs12:08

    Diagonal Method to Measure Synergy Among Any Number of Drugs

    Published on: June 21, 2018

    18.8K
    High-throughput Identification of Synergistic Drug Combinations by the Overlap2 Method07:51

    High-throughput Identification of Synergistic Drug Combinations by the Overlap2 Method

    Published on: May 21, 2018

    12.0K

    相关概念视频

    Drug-Receptor Interaction: Antagonist01:28

    Drug-Receptor Interaction: Antagonist

    An antagonist is a drug that binds strongly to a receptor without activating it. An antagonist prevents other molecules, such as neurotransmitters or hormones, from binding to the receptor and triggering a cellular response. Such interaction effectively hinders the normal physiological processes mediated by the receptor, resulting in various pharmacological effects depending on the specific receptor targeted.
    Antagonists can be classified as competitive or noncompetitive based on their...
    3.5K
    Quantitative Aspects of Drug-Receptor Interaction01:30

    Quantitative Aspects of Drug-Receptor Interaction

    The receptor occupancy theory connects a drug's response to the number of occupied receptors. With higher drug concentrations, more receptors are occupied, leading to increased responses. The formation of drug-receptor complexes involves association and dissociation rates, which reach equilibrium when the forward and backward reactions are equal. The equilibrium association constant (Ka) and its inverse, the equilibrium dissociation constant (Kd), indicate drug affinity. Higher Ka and lower...
    1.2K
    Structure-Activity Relationships and Drug Design01:28

    Structure-Activity Relationships and Drug Design

    Drug design is a dynamic field that involves discovering and developing new medications based on specific biological targets. This process heavily relies on structure-activity relationships (SAR) and quantitative structure-activity relationships (QSAR) to guide the design and optimization of efficient drugs.
    SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence...
    1.1K
    Drug-Receptor Interactions01:29

    Drug-Receptor Interactions

    Drug-receptor interaction describes the binding of receptors by drugs, but not all drug-receptor interactions result in activation and tissue response. For instance, the binding of agonists activates the receptor to generate a cellular reaction, while antagonists bind to receptors without causing their activation.
    Several parameters, such as the drug's affinity for its receptor and its efficacy, which is its ability to activate the receptor, determine the drug's effect on the tissue....
    6.0K
    Drug-Receptor Interaction: Agonist01:25

    Drug-Receptor Interaction: Agonist

    Agonists are drugs that interact with specific receptors in the body to produce a biological response. When an agonist binds to a receptor, it activates or enhances the receptor's function, leading to physiological effects. The interaction between agonist drugs and receptors is crucial for their therapeutic action in various medical treatments.
    Agonists can bind to receptors in different ways. Some agonists bind directly to the receptor's active site, mimicking the endogenous...
    2.8K
    Combined Effects of Drugs: Antagonism01:30

    Combined Effects of Drugs: Antagonism

    The combined effects of drugs can result in various interactions, of which an important type is antagonism. Antagonism is a mechanism where one drug inhibits or counteracts the effects of another drug. Antagonism can occur through various means, including receptor binding, allosteric modulation, functional interaction, chemical reactions, and pharmacokinetic processes.
    The most common type is receptor antagonism, where one drug acts as an antagonist to block the effects of another drug by...
    9.3K