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Updated: Sep 15, 2025

Helical Organization of Blood Coagulation Factor VIII on Lipid Nanotubes
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因子IXa和因子X影响因子VIIIa的稳定性和失活机制在体外和体外

Johnathan J Morris1, Nicole A Parsons1, Amelia R Wilhelm2

  • 1Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States.

Blood
|July 15, 2025
PubMed
概括

了解八因子 (FVIII) 如何失活是治疗血友病A的关键. 这项研究表明,与FIXa和FX的相互作用,以及A2域解离和APC裂变,调节FVIIIa活动,并可以改善治疗.

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