使用五种不同的方法,探索单个和混合挥发性化合物与保留比率受损螺旋计之间的潜在关联
Chenyuan Deng1, Yu Jiang1, Yuechun Lin1
1Department of Thoracic Surgery and Oncology, the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou 510120, China.
Ecotoxicology and environmental safety
|July 15, 2025
概括
挥发性有机化合物 (VOC) 与保持比率受损的螺旋计 (PRISm) 有关,炎症起着调解作用. 机器学习模型通过将VOC暴露与人口因素相结合来改善PRISm识别.
科学领域:
- 环境健康 环境健康
- 肺部病理学 肺部病理学
- 毒理学 毒理学 毒理学
背景情况:
- 环境污染物和呼吸系统健康之间的联系是已知的,但挥发性有机化合物 (VOC) 和保存比例受损螺旋计 (PRISm) 之间的关联仍然未被探索.
- 系统性炎症指数 (SII) 是系统性炎症的公认标志物,也是环境污染物和呼吸道疾病之间的潜在调解者.
研究的目的:
- 调查单个和组合的VOC与PRISm之间的联系.
- 探索SII在VOC和PRISM之间的关系中的潜在调解作用.
主要方法:
- 对来自2616名参与者的NHANES数据 (2007-2012) 的分析.
- 使用多变量后勤回归,加权量子总和 (WQS) 回归,量子g计算 (qgcomp) 和贝叶斯内核机器回归 (BKMR) 来评估VOC-PRISm关联.
- 采用机器学习模型,包括LightGBM和Shapley添加式解释 (SHAP) 来进行PRISM预测和特征重要性分析.
主要成果:
- 的1 ng/mL增加与PRISm患病率的26%增加有关.
- WQS,qgcomp和BKMR证实了混合VOC和PRISm之间的关联.
- 炎症介导了观察到的效果的7.69%;种族,BMI和1,4-二二是SHAP发现的关键预测因素.
结论:
- 挥发性有机物与PRISM相关,炎症可能是这种关系的媒介.
- 整合VOC和人口数据的机器学习方法可以增强PRISM识别.
- 研究结果支持制定针对VOC相关呼吸道问题的有针对性的预防和干预策略.
相关概念视频
Factors Affecting Pulmonary Ventilation
1.6K
Besides the pressure difference between the external environment and the lungs, the airflow rate and ease of pulmonary ventilation are also influenced by three other factors: surface tension of the fluid in the alveoli, compliance of the lungs, and airway resistance.
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
1.6K
Respiratory Volumes
1.7K
Respiratory volumes are crucial metrics, meticulously measured to quantify the air exchanged in and out of the lungs during various phases of the breathing cycle. These precise measurements are vital for assessing lung function, diagnosing respiratory conditions, and monitoring overall respiratory health. Each parameter provides specific insights into the mechanics of breathing and the functional capacity of the lungs.
Tidal Volume (TV) Tidal volume (TV) is the air inhaled or exhaled in a...
Tidal Volume (TV) Tidal volume (TV) is the air inhaled or exhaled in a...
1.7K
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
2.6K
Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
Medical History
2.6K
Pulmonary Function Tests
436
Pulmonary Function Tests (PFTs)
Pulmonary Function Tests are crucial diagnostic tools for assessing respiratory function, particularly in patients with chronic respiratory disorders. They comprehensively evaluate lung volumes, ventilatory function, breathing mechanics, diffusion, and gas exchange. These tests help diagnose pulmonary diseases and play a significant role in monitoring disease progression, evaluating disability, and assessing response to therapy.
PFTs involve using a spirometer, a...
Pulmonary Function Tests are crucial diagnostic tools for assessing respiratory function, particularly in patients with chronic respiratory disorders. They comprehensively evaluate lung volumes, ventilatory function, breathing mechanics, diffusion, and gas exchange. These tests help diagnose pulmonary diseases and play a significant role in monitoring disease progression, evaluating disability, and assessing response to therapy.
PFTs involve using a spirometer, a...
436
Chronic Obstructive Pulmonary Disease-II: Pathophysiology
3.1K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
3.1K
Stimulants
324
Stimulants are substances that enhance neural activity and elevate dopamine levels in the brain, leading to their highly addictive nature. These drugs include cocaine, amphetamines, MDMA, caffeine, and nicotine, each with distinct mechanisms of action and varied health implications.
Cocaine can be administered via snorting, injection, or smoking. It primarily functions by blocking the reuptake of dopamine, resulting in a euphoric high characterized by an intense sensation of happiness and...
Cocaine can be administered via snorting, injection, or smoking. It primarily functions by blocking the reuptake of dopamine, resulting in a euphoric high characterized by an intense sensation of happiness and...
324


