整合性因果推断揭示了基因环境相互作用,将内分泌干扰物与女性不孕症联系起来
Yanggang Hong1, Zhuoyi Du2, Jiajun Li1
1The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, China; Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
Ecotoxicology and environmental safety
|July 15, 2025
概括
暴露于内分泌干扰化学物质 (EDC) 可能通过特定的基因表达变化对女性不孕症风险产生因果关系的影响. 这项研究确定了五个关键基因,为生殖健康干预提供了潜在的目标.
科学领域:
- 生殖生物学 生殖生物学
- 环境毒理学环境毒理学
- 遗传学 遗传学 是一个
背景情况:
- 女性不孕症影响全球高达12%的女性,受遗传,荷尔蒙和环境因素的影响.
- 内分泌干扰化学物质 (EDC) 是干扰荷尔蒙系统的环境剂,引发了对其对生殖健康的影响的担忧.
研究的目的:
- 研究受EDCs影响的基因表达与女性不孕症风险之间的因果关系.
- 通过基因与环境的相互作用,识别特定的基因和环境暴露与女性不育有关.
主要方法:
- 利用孟德尔的随机化 (MR) 和局部化分析来评估因果关系.
- 从TEDX和CTD数据库中分析了4207个EDC相关基因的全基因组关联数据.
- 检查了已识别的基因和常见的EDCs (如双A (BPA),四二二氧化 (TCDD) 和甲) 之间的相互作用.
主要成果:
- 五个基因与女性不孕症风险有显著关联:SULT1B1,MAST和TTC39C与风险增加有关,而ESR1和AKAP13显示有保护作用.
- 局部化分析证实了不孕症和四个基因 (ESR1,TTC39C,AKAP13,SULT1B1) 之间的共同因果变异.
- 确定了这些基因与特定的EDC之间的复杂分子相互作用,阐明了环境对生育能力影响的途径.
结论:
- 研究结果表明,EDC影响的基因表达与女性不孕症之间存在因果关系.
- 突出了基因环境相互作用在女性不孕症病因学中的作用.
- 为旨在减轻EDC对生殖健康影响的干预提供了潜在的分子标.
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