在患有状细胞病的儿科患者中,QT分散和T波峰至终
Hanaa H Eldash1, Rana Mostafa1, Heba A Borayek1
1Department of Pediatrics, Faculty of Medicine, Fayoum University, Fayoum, Egypt.
Journal of electrocardiology
|July 15, 2025
概括
患有状细胞病和状血症的儿童表现出心脏再极化变化,增加心律失常风险. 心声和心电图显示这些年轻患者的QT间隔延长和T波异常.
科学领域:
- 儿童心脏病学 儿童心脏病学
- 血液学 血液学 血液学
- 心血管研究研究心血管研究
背景情况:
- 状细胞病 (SCD) 和状血症是具有潜在心脏并发症的遗传性血液疾病.
- 心脏再极化异常是心律失常和心脏突然死亡的已知危险因素.
研究的目的:
- 为了研究心脏再极化变化和儿科SCD和状血病患者的心律失常风险.
- 为了比较患者和健康对照之间的心电图 (ECG) 和心声图参数.
主要方法:
- 观察性病例控制研究,涉及20名SCD患者,20名状血病患者和40名健康对照.
- 进行了临床评估,例行心声学,组织多普勒成像 (TDI) 和长条带心电图.
- 分析的重点是QT,修正QT (QTc),QT分散 (QTd),T波峰至终 (Tp-e) 间隔,Tei指数和e'波速度.
主要成果:
- 与对照组相比,SCD和状血症组的QT,QTc和QTd间隔显著延长 (p=0.001).
- 在患者组中观察到较高的Tp-e间隔,Tei指数和e'波速 (p<0.05).
- 在QTc/QTd和估计的肺动脉压力,IVCT,Tei指数和s'波速之间发现了正相关性.
结论:
- 患有SCD和状血症的儿童表现出延长的QTc,QTd和Tp-e间隔,表明恶性心律不整的风险增加.
- 延长的QTc与左心室功能障碍,肺高血压和心脏尺寸改变有关.
- 这些发现强调了儿童SCD和状血病患者心脏监测的必要性.
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