在生育年龄妇女的怀孕保护处方RAS抑制剂或他类药物:队列研究
Sebastian Kinnberg Nielsen1, Anders Holt1, Morten Lamberts1
1Department of Cardiology, Copenhagen University Hospital - Herlev and Gentofte, Gentofte Hospitalsvej 6, DK-2900 Hellerup, Denmark.
The American journal of medicine
|July 15, 2025
概括
许多生育年龄的女性服用雷宁-血管新生素系统抑制剂 (RASIs) 和他类药物等致死性药物,并未处方避孕药,这构成了公共卫生风险.
科学领域:
- 生殖健康 生殖健康
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 列宁- ангиотензин 系统抑制剂 (RASI) 是已知的致病原体.
- 类他类药物具有潜在的致病性.
- 在生育年龄的妇女中,评估与避孕药物一起使用药物对于预防不良妊娠结果至关重要.
研究的目的:
- 检查RASI和他类药物的处方模式.
- 为了评估生育年龄妇女同时使用避孕药的情况,这些药物被处方.
- 为了确定与毒性药物暴露相关的潜在公共卫生风险.
主要方法:
- 用于识别年龄在15-50岁的女性的全国性注册表,在2000-2023年期间处方RASIs,他类药物或通道阻塞剂 (CCBs).
- 同时的避孕措施分为口服药片,植入物,子宫内避孕装置 (IUD) 或不使用.
- 假设的保护持续时间:口服避孕药180天,植入物2年,宫内节育器4年.
主要成果:
- 包括141,351名接受RASI,79,814名服用他类药物和86,173名服用CCB的女性.
- 避孕措施覆盖率:RASI使用者为32.8%,他类药物使用者为25.2%,CCB使用者为30.8%.
- 口服避孕药是最常见的方法 (约. 66%) 在RASI和他类药物使用者中.
结论:
- 相当数量的生育年龄的妇女被处方为原性RASI或他类药物,但并未同时使用避孕药.
- 这表明,意外的原性暴露对公众健康构成风险.
- 需要进一步的研究来确定怀孕期间此类暴露的程度和影响.
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