糖醇基托桑改性碳点为基础的花样纳米平台,用于协同灭菌和促进受感染的伤口愈合
Xiaohong Chu1, Zhihan Liu1, Wenjing Wang1
1State Key Laboratory of Macromolecular Drugs and Large-scale Preparation, School of Pharmaceutical Sciences and Food Engineering, Liaocheng University, Liaocheng 252059, China.
ACS applied materials & interfaces
|July 15, 2025
概括
一个新的pH响应纳米平台,CMPG,通过协同光动力学和光热效应有效地准和消除细菌. 这种先进的材料通过减少细菌负载和增强组织修复,显著促进伤口愈合.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术纳米技术
- 传染病研究 传染病研究
背景情况:
- 细菌感染带来了重大的公共卫生挑战,需要先进的治疗策略.
- 目前针对受感染伤口的治疗方法往往缺乏多功能性和有针对性的治疗.
- 人们迫切需要智能纳米平台,能够根据需求进行抗菌和抗炎作用.
研究的目的:
- 开发一个多功能,pH响应的纳米平台 (CMPG) 用于协同抗菌和伤口愈合应用.
- 调查CMPG纳米平台的联合光动力学和光热抗菌疗效.
- 评估CMPG在促进受感染伤口愈合方面的治疗潜力.
主要方法:
- 通过修改Cu-doped NIR光触发CDs@MoS2纳米颗粒与聚多巴胺 (PDA) 和糖醇奇托 (GCS) 构建CMPG纳米平台.
- 评估pH触发的电荷逆转,用于在酸性微环境中的向细菌输送.
- 在NIR照射下对协同光动力学和光热抗菌活性的评估.
- 转录组分析以阐明细胞内抗菌机制.
- 在体内进行伤口愈合实验,以评估治疗疗效.
主要成果:
- 通过光热和光动力学效应,CMPG通过光热和光动力学效应显示出高的抗菌率 (大肠杆菌为99.74%,金色杆菌为99.51%).
- 聚多巴胺涂层控制了活性成分的释放,最大限度地减少了正常组织的损伤.
- 由于pH触发的电荷逆转,CMPG在酸性环境中表现出有效的细菌向.
- 转录组分析证实了CMPG对细菌生物活动的抑制.
- CMPG显著促进了伤口愈合,通过增强血管生成和原沉积,实现了97.03%的恢复率.
结论:
- CMPG纳米平台为治疗细菌感染和促进伤口愈合提供了一个有前途的多功能方法.
- 它的协同抗菌和抗炎特性,加上有针对性的输送,突出了其治疗潜力.
- 这项研究为开发用于按需治疗的先进抗微生物材料提供了宝贵的见解.
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