[鲁克索利提尼布,传播性结核病和原发性骨髓纤维化:一个案例研究]
A Gérard1, V Cauhape2, J Courjon2
1Service de pharmacovigilance, hôpital de Cimiez, 4, avenue Reine-Victoria, 06003 Nice cedex 1, France.
Revue des maladies respiratoires
|July 15, 2025
概括
针对骨髓纤维化症的鲁克索利提尼布治疗可以重新激活潜伏结核病. 一名患者在经过28个月的鲁克索利提尼布治疗后,在没有先前对潜在感染进行查的情况下发展出传播性结核病.
科学领域:
- 在瘤学瘤学.
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 卢克索利提尼布是一种Janus激酶2抑制剂 (JAK2i),用于治疗原发性骨髓纤维化.
- JAK2抑制剂增加了细菌和病毒感染的风险,包括结核病的重新激活.
- 在开始JAK2抑制剂治疗之前,潜伏结核病感染查至关重要.
研究的目的:
- 报告与ruxolitinib治疗的患者传播性结核病重新激活的病例.
- 强调治疗前对潜伏结核病感染进行查的重要性.
主要方法:
- 一个80岁的病人患有JAK2V617F突变原发性髓纤维化病例报告.
- 患者接受了28个月的ruxolitinib治疗,没有进行治疗前结核病查.
- 对临床表现,诊断工作和治疗结果的分析.
主要成果:
- 患者患有扩散性结核病,骨,腹和淋巴结都受到广泛影响.
- 肺结核的重新激活发生在开始使用ruxolitinib后16个月,诊断延迟了12个月.
- 用四重抗结核疗法治疗导致缓慢改善,并停止使用ruxolitinib.
结论:
- 在开始使用ruxolitinib之前,对潜伏结核病感染进行系统免疫查是必不可少的.
- 这一建议甚至适用于结核病发病率较低的地区.
- 积极查可以预防与JAK2抑制剂治疗相关的严重传播感染.
相关概念视频
Pulmonary Tuberculosis I
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
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Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
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The first classification is based on the development of the disease, and it includes the following categories:
The first classification is based on the development of the disease, and it includes the following categories:
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Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
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Tuberculosis
Tuberculosis (TB) remains a significant global health concern, primarily targeting the lungs and spreading through airborne transmission. Infection begins when aerosolized droplet nuclei, expelled by an individual with active TB, are inhaled by another person. These microscopic particles carry Mycobacterium tuberculosis, the causative agent of TB. Upon reaching the alveoli, the bacilli are engulfed by alveolar macrophages. However, due to their specialized lipid-rich cell wall, these pathogens...


