放射治疗对鼻癌患者静脉功能的影响
Pei Fen Cheah1, Jeyasakthy Saniasiaya1, Po Lin Ooi2
1Department of Otorhinolaryngology, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia.
概括
鼻癌 (NPC) 的放射治疗显著损害了前庭功能,特别是半圆通道 (SCC),导致前庭眼反射 (VOR) 增加减少. 这种功能障碍是渐进的和剂量依赖的,影响患者.
科学领域:
- 耳鼻喉科和辐射瘤学
- 垂体系统的功能 垂体系统功能
- 头部和部癌症 治疗 治疗
背景情况:
- 在鼻癌 (NPC) 放射治疗期间,静脉末端器官被认为是低风险的风险器官 (OAR).
- 关于放射治疗对NPC幸存者的前庭功能影响的数据有限.
- 这项研究调查了辐射对半圆通道 (SCC) 的影响,后辐射NPC患者.
研究的目的:
- 为了确定放射治疗对前庭功能的影响,特别是半圆通道 (SCC) 功能.
- 为了评估前庭眼反射 (VOR) 增益和NPC患者治疗后的萨卡德存在.
- 为了将VOR参数与尾的辐射剂量相关联.
主要方法:
- 视频头脉冲测试 (VHIT) 和成人头障碍清单 (DHI) 用于评估.
- 31名接受辐射后NPC患者与36名健康对照者进行了比较.
- 在个别的SCC中测量了VOR增益和萨卡德发生,并与平均耳辐射剂量相关联.
主要成果:
- 照射后的NPC患者在大多数SCC中显著减少了VOR增益,特别是在右侧和左侧前部SCC.
- 降低的VOR增益与更高的DHI得分相关,表明头障碍增加.
- 减少的VOR增益在放射治疗后的3个月内持续存在,并且是剂量依赖的,右侧SCC松动与耳辐射剂量相关.
结论:
- 影响SCC的静脉功能缺陷存在于经辐射后NPC患者中.
- 观察到的前体功能障碍是随着时间的推移而逐渐的.
- 静脉功能下降与半圆形通道接收的辐射剂量直接相关.
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