反向信号控制着光合作用相关位点的染色质状态的动态变化
Marti Quevedo1,2, Ivona Kubalová3, Alexis Brun3
1Umeå Plant Science Centre, Department of Plant Physiology, Umeå University, Umeå, SE-901 87, Sweden. marti.quevedo@cragenomica.es.
Nature communications
|July 15, 2025
概括
塑逆行信号启动表观遗传重编程,在光合作用基因中切换基因组甲基化到乙化. 这一过程涉及特定的转录因子,对于在植物细胞中建立光合作用至关重要.
科学领域:
- 植物生物学 植物生物学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 分子生物学分子生物学
背景情况:
- 器官的逆行信号调节核基因表达和细胞能量代谢.
- 塑逆行信号在光合作用过程中改变染色质状态的作用尚不清楚.
研究的目的:
- 研究塑逆行信号是否通过改变光诱导光合作用过程中的染色质状态来控制核基因表达.
- 在Arabidopsis thaliana细胞培养中,在绿化过程中绘制基因组修饰的图谱.
主要方法:
- 使用Arabidopsis thaliana细胞培养来进行时间分辨.
- 在绿化过程中绘制了四个关键的组素修饰.
- 研究了转录因子VAL1,REF6和GLKs的作用.
主要成果:
- 在绿化过程中发现了连续和独特的表观遗传重编程事件.
- 在光合作用相关的位置展示了塑逆行信号依赖的切换器,从胰岛素甲基化到乙化.
- 链接转录因子VAL1,REF6和GLKs到光合作用基因激活之前的H3K27ac沉积.
结论:
- 塑逆行信号对于光合作用过程中的表观遗传重编程至关重要.
- 反向信号影响染色质状态的变化,对植物细胞适应光和光合作用功能至关重要.
相关概念视频
Chromatin Position Affects Gene Expression
23.7K
Chromatin is the massive complex of DNA and proteins packaged inside the nucleus. The complexity of chromatin folding and how it is packaged inside the nucleus greatly influences access to genetic information. Generally, the nucleus' periphery is considered transcriptionally repressive, while the cell's interior is considered a transcriptionally active area.
Topologically Associated Domains (TADs)
The 3-dimensional positioning of chromatin in the nucleus influences the...
Topologically Associated Domains (TADs)
The 3-dimensional positioning of chromatin in the nucleus influences the...
23.7K
Cell Signaling in Plants
5.8K
Plant cells communicate to coordinate their cycle of growth, flowering and fruiting, and activities in roots, shoots, and leaves in response to the changing environmental conditions. Plant signaling is distinct from animal signaling. Plants primarily utilize enzyme-linked receptors, whereas the largest class of cell-surface receptors in animals are G-protein coupled receptors (GPCRs). Unlike animals, receptor tyrosine kinases are rare in plants. Instead, plants have a diverse class of...
5.8K
Chromatin Modification in iPS Cells
1.9K
Chromatin modification alters gene expression; therefore, scientists can add histone-modifying enzymes, histone variants, and chromatin remodeling complexes to somatic cells to aid reprogramming into pluripotent stem (iPS) cells.
Compact chromatin makes reprogramming difficult. Enzymes, such as histone demethylases and acetyltransferases, are often added during reprogramming to loosen the chromatin, making the DNA more accessible to transcription factors. Molecules that inhibit histone...
Compact chromatin makes reprogramming difficult. Enzymes, such as histone demethylases and acetyltransferases, are often added during reprogramming to loosen the chromatin, making the DNA more accessible to transcription factors. Molecules that inhibit histone...
1.9K
Photoreceptors and Plant Responses to Light
25.2K
Light plays a significant role in regulating the growth and development of plants. In addition to providing energy for photosynthesis, light provides other important cues to regulate a range of developmental and physiological responses in plants.
25.2K
Position-effect Variegation
6.6K
In 1928, a German botanist Emil Heitz observed the moss nuclei with a DNA binding dye. He observed that while some chromatin regions decondense and spread out in the interphase nucleus, others do not. He termed them euchromatin and heterochromatin, respectively. He proposed that the heterochromatin regions reflect a functionally inactive state of the genome. It was later confirmed that heterochromatin is transcriptionally repressed, and euchromatin is transcriptionally active chromatin.
6.6K
Epigenetic Regulation
31.4K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
31.4K


