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Updated: Sep 15, 2025

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在HR修复过程中,PCAF介导的乙化调节了RAD51在染色质上的动态定位

Jiajia Hou1, Munan Shi1, Jialu Hong1

  • 1Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, 1 Wen Yuan Road, 210023, Nanjing, China.

EMBO reports
|July 15, 2025
PubMed
概括

PCAF (p300关联因子) 通过乙化RAD51来调节同源重组修复,促进其降解. 这会影响DNA修复,耐药性和癌症的进展.

关键词:
同源重组的同源重组这是一个PCAFAF.蛋白质的稳定性 蛋白质的稳定性在RAD51中使用RAD51.

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