基于NHANES数据的预后营养指数和结直肠癌风险之间的线性反向关联
Youwei Han1, Peng Zhou1,2, Liping Wang2
1Department of General Surgery, The Affiliated Wuxi No.2 People's Hospital of Nanjing Medical University, Wuxi, China.
Scientific reports
|July 15, 2025
概括
较高的预后营养指数 (PNI) 评分与较低的结直肠癌 (CRC) 风险有关. 这项研究表明,PNI可以帮助识别CRC风险较高的个体,从而有可能改善查策略.
科学领域:
- 在瘤学瘤学.
- 营养生物标志物 营养生物标志物
- 流行病学 流行病学
背景情况:
- 预后营养指数 (PNI) 是癌症患者的一个关键预后标志物.
- PNI与结直肠癌 (CRC) 风险之间的关联尚未完全理解.
- 一个假设认为,较低的PNI水平与CRC风险增加有关.
研究的目的:
- 研究PNI水平与发展CRC的风险之间的关系.
- 确定PNI是否可以作为CRC风险的预测生物标志物.
- 探索PNI在加强大规模CRC查举措中的实用性.
主要方法:
- 使用了来自国家健康和营养检查调查 (NHANES) (2007-2016) 的数据.
- 包括26,229名参与者 (≥20岁);不包括那些缺乏PNI计算 (血清白蛋白,淋巴细胞计数) 或瘤史数据的参与者.
- 采用多变量逻辑回归,受限立方线分析和子组分析,以多次归算调整共变量.
主要成果:
- 在较高的PNI得分和较低的CRC几率之间发现了显著的反向线性关系.
- 每增加1个单位的PNI与CRC几率减少6.43%有关 (OR:0.9357;p=0.005).
- 这种关联在各种人口统计和临床因素中保持一致;男性显示出更明显的反相关性.
结论:
- 较高的PNI分数独立地与CRC的几率降低有关.
- 普尼显示出作为一种有价值的风险生物标志物的潜力,用于识别CRC风险较高的个体.
- PNI可能有助于改进大型CRC查策略.
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