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对粉样β寡合体结合物的基因编码的选择

ByungUk Lee1, John A Mannone1, Tina Wang2

  • 1Department of Chemistry, University of Wisconsin-Madison, Madison, WI, USA.

Nature chemical biology
|July 15, 2025
PubMed
概括

研究人员开发了一种生物传感器,用于检测阿尔茨海默病中有毒的粉样β寡合体 (AβO). 这种工具可以快速识别强大的结合蛋白,加速神经退行性疾病的新诊断和治疗方法的发现.

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Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
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