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美国成年人暴露于挥发性有机化合物和肉症风险,基于NHANESES
Tian-Zhen Qu1, Yue Zhang2, Qing-Yun Huang3
1Department of General Practice, Jiangyin People's Hospital, Shoushan Road 163, Wuxi, 214400, China.
Scientific reports
|July 15, 2025
概括
挥发性有机化合物 (VOC) 与肉症有关,这是一个肌肉消耗的疾病. 特定的VOC尿路代谢物,如ATCA,在美国成年人中显示出显著的关联,表明潜在的环境健康风险.
科学领域:
- 环境健康 环境健康
- 代谢学 代谢学 代谢学
- 老年学是一门学科.
背景情况:
- 萨科佩尼亚是一个日益严重的公共卫生问题,特别是在老年人群中.
- 挥发性有机化合物 (VOC) 是无处不在的环境污染物,具有已知的健康影响.
- 挥发性有机化合物暴露和肉症之间的关系仍未得到充分研究.
研究的目的:
- 调查美国成年人尿液中VOC代谢物 (mVOCs) 与肉症之间的关联.
- 为了确定与肉症风险相关的特定mVOCs.
- 探索这种关系中的潜在调解因素.
主要方法:
- 来自NHANES (2011-2018) 的3,391名美国参与者 (年龄在20-59岁) 的数据分析.
- 多变量逻辑回归用于评估特定的mVOC与肉类的关联.
- 先进的统计方法,包括加权量子总和 (WQS) 和贝叶斯核机回归 (BKMR) 用于混合物分析.
- 调解分析以确定高密度脂蛋白 (HDL) 的作用.
主要成果:
- 在萨尔科佩尼亚和CEMA (亚克罗林代谢产物),CYMA (亚克利龙代谢产物),ATCA (化物代谢产物) 和3,4-MHA (西代谢产物) 之间发现了显著的关联.
- 通过WQS和BKMR分析,ATCA被确定为肉症风险的关键因素.
- 在男性和女性中都观察到相关性,HDL部分调解了效果 (3.8%).
结论:
- 挥发性有机化合物的尿中代谢物与美国成年人的肉症有显著的关联.
- 特定的mVOCs,特别是ATCA,可能在肉症的发展中发挥作用.
- 需要进一步的纵向研究来确认因果关系并阐明生物机制.
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