相对脂肪量 (RFM) 和慢性病 (CKD) 之间的关联:来自NHANES 2005-2018年的数据
Zhendong Wang1,2, Wenxuan Li1, Lina Lv2
1Department of Nephrology, Qilu Hospital, Shandong University, Jinan, China.
Scientific reports
|July 15, 2025
概括
较高的相对脂肪量 (RFM) 与慢性病 (CKD) 风险增加有关. 这种联系表明RFM可能是CKD研究和患者监测的有价值指标.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 代谢健康 代谢健康
- 生物统计学 生物统计学
背景情况:
- 相对脂肪量 (RFM) 是一种新兴的体脂成分指标.
- 慢性病 (CKD) 是一个重要的全球健康问题.
- 了解CKD的新风险因素对于预防和管理至关重要.
研究的目的:
- 调查相对脂肪量 (RFM) 和慢性病 (CKD) 之间的关联.
- 探索RFM-CKD关系中的潜在调解因素.
主要方法:
- 使用了国家健康和营养检查调查 (NHANES) 数据 (2005-2018).
- 采用后勤回归,子组分析,限制立方线 (RCS) 建模和调解分析.
- 评估了RFM,体重指数 (BMI),腰围 (WC) 和CKD患病率之间的关系.
主要成果:
- 在更高的RFM和增加的CKD风险之间观察到正相关性.
- 在最高的RFM四分位数中的个人显示显著增加了CKD风险 (OR = 1.82).
- 中性细胞对淋巴细胞的比率,血红蛋白,糖化血红蛋白和尿酸被确定为调解剂,血红蛋白显示出保护作用.
结论:
- 相对脂肪量 (RFM) 与慢性病 (CKD) 独立相关.
- 在CKD研究和临床实践中,RFM可以作为一个有用的指标.
- 进一步研究调解途径,特别是血红蛋白的作用是有必要的.
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