使用PROMISE V2和使用Ga/F-PSMA PET/CT的aPROMISE进行手动诊断的诊断性能比较
Yuki Enei1, Takafumi Yanagisawa2, Atsuya Okada3
1Department of Urology, The Jikei University School of Medicine, 3-19-18, Nishi-Shimbashi, Minato-Ku, Tokyo, 105-8471, Japan.
Annals of nuclear medicine
|July 15, 2025
概括
自动化PROMISE (aPROMISE) 软件在日本患者中使用PSMA PET/CT显著减少了使用PSMA PET/CT进行前列腺癌分期的诊断时间. 虽然对骨转移精确,但aPROMISE需要对淋巴结和内脏转移检测进行改进.
科学领域:
- 核医学就是核医学.
- 放射学 放射学是一门学科.
- 人工智能在医学中的应用
背景情况:
- 自动化PROMISE (aPROMISE) 软件,这是PSMA PET/CT的AI工具,显示出诊断效用.
- 之前的研究主要使用18F-PSMA PET/CT.
- 这项研究评估了日本转移性前列腺癌 (mPCa) 患者的18F和68Ga-PSMA PET/CT aPROMISE.
研究的目的:
- 为了研究aPROMISE的诊断效用,使用18F-和68Ga-PSMA PET/CT.
- 为了比较手动诊断和PROMISE辅助诊断之间的诊断时间和对应率.
- 评估两种放射性同位素之间的诊断性能差异.
主要方法:
- 对21名mPCa患者的21次PSMA PET/CT扫描 (12 68Ga, 9 18F) 的回顾性评估.
- 核放射科医生使用PROMISE V2.2进行手动诊断.
- aPROMISE辅助诊断用于miTNM分期和转移部位评估.
主要成果:
- aPROMISE显著减少了诊断时间 (中位数为427s与1114s,p<0.001),特别是68Ga-PSMA PET/CT.
- 对于miT,M1a和M1b阶段的高灵敏度 (100%),对于M1b的100%灵敏度/特异性,不论放射性同位素.
- 由于淋巴结缺失和内脏转移 (上腺,肝脏) 的原因,对miM1c的敏感性较低 (63%).
结论:
- aPROMISE辅助诊断为mPCa分期提供了缩短的时间和令人满意的准确性.
- 有效检测骨转移,但在淋巴结和内脏转移的识别方面存在局限性.
- 支持aPROMISE在日本mPCa患者中的实用性,因此需要更大的队列验证.
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