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在健康的女性人口中,侧侧上臂淋巴通路的主要解剖变异
James E Fanning1, Madeleine Givant1, Angela Chen1
1Division of Plastic and Reconstructive Surgery, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, 110 Francis St, Suite 5A, Boston, MA, 02215, USA.
Breast cancer (Tokyo, Japan)
|July 15, 2025
概括
侧侧上臂 (LUA) 路径对于淋巴排水至关重要,在健康个体中显示出差异. 了解这些LUA通路变异对于评估与乳腺癌相关的淋巴胀风险至关重要.
科学领域:
- 人体解剖学 解剖学 解剖学
- 淋巴系统 淋巴系统
- 医疗成像医学成像
背景情况:
- 侧侧上臂路径 (LUA) 是一个绕过股的表面淋巴路径.
- 该路径的解剖学变异与乳腺癌相关的淋巴 (BCRL) 风险和骨淋巴结解剖后的风险 (ALND) 有关.
- 在健康人群中,LUA通路变异的发生率以前没有报告.
研究的目的:
- 在健康的女性群体中确定侧侧上臂 (LUA) 路径变化的发生率和特征.
- 在没有结节疾病的个体中建立LUA通路解剖学的基线.
主要方法:
- 在45名健康的女性志愿者中使用绿色氨酸 (ICG) 淋巴图的双边淋巴图绘制.
- 在手/手腕和上臂的六个标准部位注射ICG.
- 记录LUA路径变化:捆绑表型 (长,短,缺席),近位排水位和前臂路径贡献.
主要成果:
- 在90个被评估的手臂中,在99%的手臂中确定了LUA通路.
- 长束现型发生在71%的手臂中,而短束在28%中.
- 在89%的手臂中,LUA通路被排到deltopectoral槽,在11%的手臂和下.
结论:
- 在健康的手臂中观察到的长和短类型的比例与乳腺癌患者的比例相当.
- 在一般人群中确定LUA通路变异的发生率至关重要.
- 路径的变化可能会影响个体对发展BCRL的敏感性.
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