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Updated: Sep 15, 2025

Techniques to Induce and Quantify Cellular Senescence
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Published on: May 1, 2017

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p38基因激活蛋白激酶驱动CD4+T淋巴细胞的衰老,并增加它们的病理潜力

Luis González-Osuna1, Sandra Yasuyo Fukada2, María Paz Hernández-Cáceres3,4

  • 1Periodontal Biology Laboratory, Faculty of Dentistry, Universidad de Chile, Santiago, Chile. luisgodont@gmail.com.

Immunity & ageing : I & A
|July 15, 2025
PubMed
概括

p38 MAPK驱动CD4+ T淋巴细胞衰老,导致线粒体功能障碍和炎症性SASP. 阻断p38 MAPK可以逆转这些影响,突出其在免疫衰老和炎症性疾病中的治疗潜力.

关键词:
有CD4阳性的T-淋巴细胞.细胞衰老 细胞衰老线粒细胞衰变 (mitophagy) 是一种细胞衰变的过程.在 SASP 找 SASPp38 MAPKK 的一个.

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